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Ruthenium-catalyzed hydrogenation of aromatic ketones using chiral diamine and monodentate achiral phosphine ligands

Abstract

The Ru-catalyzed asymmetric hydrogenation of ketones with chiral diamine and monodentate achiral phosphine has been developed. A wide range of ketones were hydrogenated to afford the corresponding chiral secondary alcohols in good to excellent enantioselectivities (up to 98.1% ee). In addition, an appropriate mechanism for the asymmetric hydrogenation was proposed and verified by NMR spectroscopy.

Funding source: National Natural Science Foundation of China (21601039, 21562010).
Related subjects: Production & Supply Chain
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/content/journal2073
2021-03-13
2021-07-24
http://instance.metastore.ingenta.com/content/journal2073
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